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Sen. Kyrsten Sinema on Thursday night offered critical support for President Joe Biden's domestic agenda after party leaders agreed to change new tax proposals at her request.

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She indicated she would "move forward" on Democrats' sweeping economic package that has been the product of intensive negotiations for more than a year.

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Sinema's support means Democrats likely will have 50 votes in their caucus to push the bill through their chamber by week's end, before it moves to the House next week for final approval.

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And while the plan is scaled back from Biden's initial Build Back Better package, the latest bill -- named the Inflation Reduction Act -- would represent the largest investment in energy and climate programs.

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A review by Senate parliamentarian Elizabeth MacDonough, who must decide whether the provisions in the bill meet strict rules to allow Democrats to use the filibuster-proof budget process to pass the legislation along straight party lines.

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But after days of talks with Senate Majority Leader Chuck Schumer, Sinema indicated she was ready to vote to proceed.

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"Subject to the Parliamentarian's review, I'll move forward," she said in a statement after maintaining silence over the bill for more than a week.

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"We have agreed to remove the carried interest tax provision, protect advanced manufacturing, and boost our clean energy economy in the Senate's budget reconciliation legislation," Sinema said.

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